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In Vitro Synergistic Cytotoxic Effect of Triptolide Combined With Hydroxycamptothecin on Pancreatic Cancer Cells
Insects 12, 32
in vitro experiments showed that SGK1 knockdown alleviated erastin-induced downregulation of Slc7a11, GPX4, GSH, and GSSG, while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting that SGK1 modulates ferroptosis processes through inflammatory pathways in CHD (44)
Carnitine serves an essential role in fat metabolism
GSH is a major scavenger of reactive oxygen species (ROS) 26 and plays a critical role in detoxification of potential alkylating agents in the liver 49
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