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Interestingly, there is more recent evidence to support a potential cancer suppressing effect of MT-II independent of photoprotective effects when applied in a topical formulation to melanomas in rodents [26]
Conversely, lactylation of lysine-specific demethylase 1 (LSD1) in melanoma promotes its interaction with Fos-like antigen 1 (FosL1), resulting in repression of TFRC-mediated iron uptake and conferring resistance to ferroptosis (70)
Swiss Med Wkly 147:w14367
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