Potential Side Effects Linked to Receptor Activity The most common side effects in phase 2 trials were gastrointestinal, including nausea, vomiting, and diarrhoea, consistent with GLP-1R agonist class effects
Epub 2011/04/05
Call your healthcare provider right away if you have any mental changes that are new, worse or worry you
This usually occurs when theres not enough sulfur group (-SH) available for detoxification, leading to increased oxidative stress
However, no Phase II or Phase III randomized controlled trials have been published as of 2026, meaning the full safety profile particularly long-term effects, drug interactions, and dose-dependent risks remains incompletely characterized
Both were discontinued in 2008 and FDA withdrew the approvals in June 2009, not for reasons of safety or effectiveness