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In healthy older adults, IGF-1 concentrations decline roughly 14% per decade after age 30, tracked across epidemiological data from the Baltimore Longitudinal Study of Aging 3

How GLP-1s Offer Real-World Heart Protection The evidence that GLP1-s reduce the risk of heart attack and stroke comes from large cardiovascular outcomes trials designed to measure what researchers call MACE, major adverse cardiovascular events

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Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring