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doi: 10.1038/s41416-019-0637-9 45 JiangBZhangJZhaoGLiuMHuJLinFet al

GLP-1 in Obesity: Why Weight Loss Is So Powerful GLP-1RAs reduce body weight through multiple synergistic mechanisms: Appetite suppression Delayed gastric emptying Reduced reward-driven eating Central hypothalamic satiety signalling Reduced caloric intake Hypothalamic Action GLP-1 stimulates satiety neurons: POMC/CART neurons And suppresses hunger neurons: NPY/AgRP neurons This creates sustained appetite reduction and clinically meaningful weight loss

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