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Busulfan Busulfan is an alkylating agent widely used in myeloablative conditioning regimens before bone marrow or hematopoietic stem cell transplantations 78

10.1002/mnfr.201400550 35 GalganoF.FavatiF.CarusoM.PietrafesaA.NatellaS

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Dectin-1 activation by particulate - glucans was shown to promote the production of pro-inflammatory cytokines IL-6, IL-8, and TNF- in THP-1 macrophages via co-binding with TLR2 and TLR4 (184), as also shown in Figure 4

In this context, IDO1 expression might be associated with antitumor immune responses, as a marker of M1 macrophages, but not related to the enzymatic and anti-inflammatory activity of IDO1