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Stay strong, stay curious and breathe, Robin One last thing Wondering if your hormone levels are affecting your metabolism or whether youre a candidate for HRT, a GLP-1, or both

This improvement occurs through multiple mechanisms: reduced aromatase activity as fat mass decreases, improved insulin sensitivity, decreased inflammatory cytokines, and restoration of normal hypothalamic-pituitary function

Whelton PK et al

Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM

et al., 2018

But tirzepatide proved that when GIP and GLP-1 receptors are activated together, the combination produces substantially more weight loss than either pathway alone