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When combined with stable isotope labeling, this approach allows the tracing of fatty acid substrates (e.g., DHA and EPA) through their conversion pathways and product lineages in disease models, facilitating the construction of individualized lipid mediatorPRLM network maps [315]

They should mainly be used as second-line therapy as add on to metformin in patients with type 2 diabetes who have no pre-existing cardiovascular disease and have a therapeutic goal to avoid hypoglycaemic events

These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation [50]

This platform starts with a custom home cage where mice can live continuously, but which is outfitted with an array of continuous sensors, a running wheel, and food and water dispensers that are easily monitored

[GH/IGF-1 and oncology research models: what's new in this association] [PMID: 16444368] Laboratory literature summary: [GH/IGF-1 and oncology research models: what's new in this association]