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Acknowledgements The author would like to express his deepest gratitude to the Board of Trustees of Delta University for Science and Technology for their continuous guidance, encouragement, and support throughout the course of this research

The transitions observed were m/z 598 to 380 & 601 to 380

These results are amongst the best we have ever seen

Although potential involvement of 3UTR cannot be excluded, we demonstrated that YBX1, which facilitates 5UTR-mediated HIF1A translation 38,46 , directly binds to the PRKAA1 5UTR and dictates AMPK1 protein synthesis

FIGURE 2 4 Discussion 4.1 Evolutionary patterns of antioxidase-related genes in hypoxia-tolerant lineages Hypoxia-tolerant mammals have evolved adaptive mechanisms, including oxygen binding, storage and transportation capacities ( SOD was also identified in cetaceans ( GST genes in divergent taxonomic groups, which is indicative of pervasive adaptive evolution ( min = 0.062 for GPX2 , max = 0.261 for SOD1 ), indicating that purifying selection played an important role in maintaining their function of antioxidase-related genes

Our search across three databases yielded N = 7275 papers