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Non-glutathione disulfide substrates that employ monothiol mechanism (iii) should not be trapped as Grx(SSR) intermediates, which might explain the rather small number of verified non-glutathione disulfide substrates of glutaredoxins to date
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Disruptions in detoxification and mitochondrial function may also interfere with melatonin production and restful sleep cycles
10.3390/pharmaceutics14081590 58 JonesC
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