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Is the acetate salt of a synthetic cyclic heptapeptide with the sequence cyclo-(Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10])-NH2, representing a conformationally constrained, metabolically stabilised derivative of the -MSH(4-10) pharmacophore core in which the Asp5 and Lys10 side chains are bridged by a lactam bond to form the cyclic backbone, Nle4 replaces methionine to prevent oxidative inactivation, and D-Phe7 replaces native phenylalanine to confer endopeptidase resistance and stabilise the receptor-binding pharmacophore conformation
Apical Voltage-Driven Urate Efflux Transporter NPT4 in Renal Proximal Tubule
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Cardiovasc Drugs Ther 21(6):445448
Yanagiba, K
Although the effects of the supplement were organ-specific, the supplement is promising in that it reduced reactive oxygen species production, acetylcholinesterase and superoxide dismutases activitivies, and enhanced total antioxidant capacity to levels equal to those of the baseline control group (non-stressed group)
