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The effect of polyphenols on animals with AD or other cognitive impairments Out of the included studies, 22 focused on examining the effects of polyphenols affect factors, such as inflammation, brain oxidative stress, amyloidogenic pathways, tau phosphorylation, microbial metabolites, and the integrity of the intestinal and blood-brain barrier (BBB) as well as gut microbiome composition in animals with AD or other cognitive impairments (Table 1)

Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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