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For some ROS there are endogenous desativator systems, while for the others there are external antioxidants, or even both

Given the overlapping functions listed above, members of our laboratory proposed that the AngIV/AT4 system closely interacts with the HGF/Met system [37,39,80,81]

(81) showed that de 24-h pattern of the dorsal raphe 5-HT reuptake in C57BL/6J mice under shortened photoperiods may be altered at the transcriptional level by specifically timed melatonin

because of its wide therapeutic range and pharmacological properties [182]