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Retatrutide includes GLP-1 receptor activation as one of its three mechanisms
J Clin Invest 114:495503
Healthcare professionals should counsel patients that weight lossregardless of the methodmay alter fertility status, and appropriate contraception should be reviewed and optimised as weight loss progresses if pregnancy is not desired
Poor sleep is not considered a common or expected side effect of GLP1 agonists such as Wegovy or Mounjaro
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Therefore, the strongest current claim is that glucagon receptor activation may increase energy expenditure through hepatic and systemic metabolic mechanisms , but the exact human contribution of thermogenesis requires further study
