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Vitamin B12: Fact Sheet for Health Professionals MedlinePlus, National Library of Medicine

Your healthcare team should also review your complete medication list, as stopping tirzepatide may require adjustments to other therapies

Week 21 and beyond (15mg): Maximum dose

The trough level, the lowest point just before your next injection, stays high enough to maintain therapeutic effects throughout the entire dosing interval

Int J Mol Sci 2018, 19 (9)

If you don't lose 5% of your weight after 12 weeks of taking Contrave, your doctor may tell you to stop taking it because it's unlikely to work for you, the FDA says