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Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro

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) seedlings through the enhancement of ascorbate-glutathione cycle

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Previous metabolomics profiling of these liver tissues reveals disrupted endobiotic homeostasis in UGT2B17-deficient livers, 30,31,32 characterized by elevated taurocholic acid and reduced levels of both adenine and hydroxyisovalerylcarnitine, a product of leucine metabolism (Supplementary Fig