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All three residues play a much greater role in GLP-1 mediated cAMP signalling, relative to oxyntomodulin (Figs

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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [5-, 17-, and 59-fold the maximum recommended human dose (MRHD) of 1 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (2-, 5-, and 17-fold MRHD) were administered to the females

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S., Meier, J

Survival and neurological deficit Cohorts of animals were individually labeled for identification and randomly assigned to each treatment group