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Four studies enrolled adults with BMI of 30 or greater or a BMI of 27 or greater with at least 1 weight-related comorbidity, and the average proportion of individuals without comorbidities was 24.4% (Rubino et al., 2021

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Histopathological changes in pancreatic tissue were examined by Hematoxyline & Eosin staining and the insulin content in the islet measured by immunohistochemistry with anti-insulin antibody