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This led to the US FDA approval of Ozempic to reduce cardiovascular risk in this specific patient population in 2020 In the HARMONY Outcomes trial, patients with type 2 diabetes and cardiovascular disease who took the GLP-1 medication saw a 22% reduction in major adverse cardiovascular events compared to placebo
However, this ratio demonstrated a discriminative ability comparable to those of the individual metabolites, with AUC (95% CI) values of 0.73 (0.570.89), 0.70 (0.540.86), and 0.75 (0.600.91) for aKG, creatine, and their ratio, respectively (Fig
Biochim Biophys Acta 1568(1):6773 Bouman L, Sanceau J, Rouillard D, Bauvois B (2002) Gamma-glutamyl transpeptidase expression in Ewings sarcoma cells: up-regulation by interferons
No, Lemme GLP-1 Daily is not FDA-approved
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