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DSIP for Sleep Improvement By regulating the sleep-wake cycle, DSIP is thought to help induce sleep, potentially leading to improved sleep quality and rejuvenation [4]

During the initial period of using any new transdermal medication, patients may experience local skin reactions such as mild redness, itching, or irritation at the application site

For animal studies quality assessment was performed using SYRCLEs risk of bias tool ( Results Out of a total of 1436 identified unique records ( Figure 1 ), we excluded 1372 records for not meeting the inclusion criteria based on title or abstract or upon further evaluation of the full text

doi:10.1371/journal.pone.0035683 62

Finally, we note that the model predicts modest decreases in the rate of the DNA methylation reaction (vDNMT) and this is consistent with the reported global DNA hypomethylation seen in autistic children [73]

G., Moura, F