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Additionally, magnetic resonance imaging (MRI) conducted on a subset of participants from the SURPASS-3 trial showed that, after 52 weeks of treatment with tirzepatide, liver fat content was reduced by 30% or more in 67% to 79% of participants, and VAT volume decreased by 16% to 25% [62]

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These effects are dose-dependent and typically most pronounced during the initial weeks and after each dose escalation