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Secondly, the balance of GSH and GSSG is shifted toward GSSG via the GPX and GR reactions
Reference: Kleinman HK & Sosne G (2012)
The same applies to PR
Additionally, lactate enters vascular endothelial cells via MCT1, which can activate the HIF-1 pathway and upregulate the expression of VEGFR2 and bFGF under normoxic conditions, promoting angiogenesis
doi: 10.2147/JIR.S436147 78 ZhaoBWangXZhengJWangHLiuJ
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