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A comprehensive literature search was conducted between January 1998 and May 2025 using PubMed/MEDLINE, Scopus, Cochrane CENTRAL, Clinicaltrials.gov, regulatory sources (EMA, FDA), and manual searches of high-impact journals ( NEJM , Lancet , JAMA , Diabetes Care , Obesity , Nature Medicine , Cell Metabolism )
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Budini added: Our projections show that even though people regain most of the weight they have lost, they still maintain some of the weight loss, but what we currently dont know is if the same proportion of lean mass is recovered
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However, tapering over 4-8 weeks is typically easier psychologically because it prevents a sudden hunger surge and gives your brain time to solidify new eating behaviors
This is because the concentration of semaglutide in your body is still low after only one injection
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