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32 HolstJJ

Sublingual medication works by placing the drug under the tongue, where it dissolves and is absorbed directly into the bloodstream through the tissues

All animal experiments were approved by the Institutional Animal Care and Use Committee of the College of Medicine at Gachon University (approval number: LCDI-2020-0135)

Manufacturing and Scale Considerations Injectable GLP-1 production presents complex manufacturing challenges requiring specialized facilities, cold-chain logistics, and precise formulation control

Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements

The patent also discloses that the preferred formulation of tirzepatide is by parenteral routes, such as subcutaneous, intravenous, or transdermal