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SIRT2-deficient mice exhibit increased global protein synthesis in the hearts, which may contribute to the development of cardiac hypertrophy

Targeting obesity in HF with GLP 1RAs in patients with heart failure, without and without type 2 diabetes mellitus The obesity paradox has a strong foundation in the evidence that unintentional weight loss is commonly associated with higher mortality and hospitalization risk in both HFpEF and HFrEF patients [18, 19], likely as a proxy of cachexia, widely observed in patients reaching the end-stage CVD trajectory [20]

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