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In another study performed in type 2 diabetic mice by Wang et al., labile iron content was significantly increased in myocardial tissue (38)
Flow cytometry-based examination of the ferrous iron levels in 5-FU-derived persister tumors revealed increased ferrous iron staining in these residual tumors ( Figure 5D )
These include superoxide (O 2 ), nitric oxide (NO) and their particularly reactive product, peroxynitrite (ONOO-)
3 To counteract such biological effects, organisms such as humans have evolved a number of cellular repair mechanisms
Moreover, CKD serves as a risk factor for cardiovascular disease, infections, strokes and other life-threatening conditions, underscoring its status as a global disease burden [4,5,6]
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