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Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. Small split-face human dermatology studies, usually with fewer than 50 participants per arm, report changes in wrinkle depth and skin density

Sternberg, C

Animal Nutrition 4 (1): 1116

Mechanism in research literature The mechanistic anchor for Epithalon is its activation of telomerase, the enzyme that maintains telomere length at the ends of eukaryotic chromosomes