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This likely occurs because USP8 mutations enhance its deubiquitinating activity

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Presented for research literature review only Osborne R (2008)

Follistatin blocks, indeed, the binding of myostatin to its receptor, thus preventing its activity

doi:10.1001/jamainternmed.2016.9098 Genetic analysis of 10 pedigrees with inherited retinal degeneration by exome sequencing and phenotype-genotype association