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Mood and Cognitive Function : They positively affect mood and cognitive function due to their influence on growth hormone levels and neuroprotection

This remains an important pharmacological consideration as retatrutide progresses through clinical development, and mechanistic conclusions should be regarded as provisional pending further evidence

Additionally, patients with higher baseline insulin resistance or elevated fasting glucose often require dual-action GLP-1/GIP therapy rather than single-pathway GLP-1 alone

But these symptoms typically clear up within 4 weeks

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