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Indeed, similar to clioquinol, therapeutic chelation of transition ions using desferrioxamine (DFO) or ethylenediaminetetraacetic acid (EDTA) was able to improve symptoms and slow down the progression of dementia in AD patients (Casdorph, 1981
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These trials aimed to evaluate its ability to lower serum uric acid levels, reduce gout flares, and provide anti-inflammatory effects
Previous studies have elucidated that AGE-RAGE pathway can affect bone homeostasis in multiple links, including biomineralization [57], osteogenesis [58], osteoclastic differentiation [59], etc
doi: 10.1038/s41581-021-00393-8 2 ZhengYLeySHHuFB
Acetyl-L-Carnitine (ALCAR), the acetylated derivative of carnitine, is involved in trans-mitochondrial membrane trafficking of acetyl units in catabolic and anabolic pathways
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