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It is the most clinically studied of the three, with topical trials showing collagen, fine-line, and skin-density changes, and a large body of in-vitro work on gene expression and wound healing

Cu + and Fe 2+ can convert H 2 O 2 to a highly reactive hydroxyl radical (Fenton reaction), which locally damages various biomolecules at the site of its formation

Studies frequently explore cellular signaling, actin and cytoskeletal organization, angiogenic markers, and stress-response pathways

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Experimental studies in Wistar rats treated with PZA or PA showed hepatotoxicity, as demonstrated by elevated serum alanine aminotransferase, aspartate transaminase, and galactose single-point levels (Tostmann et al., 2008