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10.1093/jxb/erj175 4 BarrosoJ
The controlled delivery of copper by GHK-Cu is hypothesised to activate Nrf2, which in turn promotes the expression of genes that help to mitigate oxidative damage
Van den Eynde et al, 2022)
Contraindications It is not recommended for use in people with certain skin conditions or disorders, due to insufficient safety data
3.1.4.3 Strategies to bridge translational difficulties To improve clinical translatability, the following strategies are recommended: (1) Multi-species validation: mechanisms discovered in mice should be validated in rats, rabbits, or non-human primates
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