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doi: 10.1016/j.archger.2007.01.029

This avoids the cold-chain challenge entirely

In a randomized, double-blind, placebo-controlled trial in 216 healthy women (25-50 years old), supplementation with a daily multivitamin/mineral for nine weeks was associated with a significant increase in speed and accuracy of performance on the Stroop color-word test (133)

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The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems