Common effects usually mild and often worst during titration include nausea, vomiting, diarrhea, constipation, abdominal pain, upset stomach, headache, and fatigue
On top of that, skin absorption is relatively low because the ingredient is water-soluble
Precursor support and direct glutathione supplementation are not interchangeable in every circumstance
J Pharmacol Exp Ther 311:99108 Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB (1994) Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary
Specific Considerations for Oral Shots or High Dose Forms Oral glutathione has limited absorption via gastrointestinal tract
Mol Aspects Med 2008