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No mysticism

If it's a creature, it can't be regenerated this turn, and if it would die this turn, exile it instead

It's largely a matter of judge opinion, so in order for this article to be most helpful, I kept it to facts about WOTC's general policy and common judge considerations- I left out any of my own opinions

It does require you to get into combat, which is a big restriction

You can also just increase Polukranos's power/toughness with something like Eldrazi Conscription, which means Polukranos will lose his counters but not die due to them