Playing Mishra's Factory in something like RDW might cost your good and average draws a small fraction of a % (total stab in the dark but we will call it 0.2%) in exchange for a slight improvement to your weaker draws
But in general, you often want to have a small number of one drops, plenty of two and three drops, and then a gradually decreasing number of four, five, and six drops
Players of Group Hug decks would answer that question with a few of their own: why are you already thinking of them as your opponents, and is beating all of them actually necessary
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First Edition Shadowless Holographic Blastoise Image from trollandtoad.com The general rule is: If its a first edition shadowless card, you may have something
How many Pack Points does it cost to craft Gothorita