Using cheap creatures with infect or toxic can make it easy to do this if your opponents arent dropping creatures on turns 1 and 2
It turns out that the answer is very
In the case of the former, its because the best choices vary not only by color identity, but often by specific deck building limitations: Seismic Assault and many other red effects want you to play an extra-high land count, while a black deck with reanimation and Tortured Existence obviously cares about discarding creatures
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These arent necessary upgrades, but they can add some fun interactions depending on how you want to tune the deck